Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra) precede the onset of type 2 diabetes (Whitehall II Study)
نویسندگان
چکیده
1 Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany; 2 Department of Epidemiology and Public Health, University College London, London, UK; 3 Institute of Biometrics and Epidemiology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany; 4 Semmelweis University, Budapest, Hungary; 5 Center for Internal Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; 6 Steno Diabetes Center, Gentofte, Denmark.
منابع مشابه
Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes
OBJECTIVE Interleukin-1 receptor antagonist (IL-1Ra), a natural inhibitor of interleukin-1 beta, has been shown to improve beta-cell function and glycemic control in patients with type 2 diabetes. The aim of this study was to investigate whether baseline systemic levels of IL-1Ra are associated with incident type 2 diabetes during more than 10 years of follow-up. RESEARCH DESIGN AND METHODS W...
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تاریخ انتشار 2008